Analysis on Nanostructured Biosensors and Devices

Explore the interactions at the nano-bio interface delving into the molecular dynamics and mechanical properties of biomolecules and cells in contact with engineered nanostructures, facilitating advancements in diagnostics, therapeutics, and biomaterials development.

Molecular bio-recognition: study the interaction between macromolecules (e.g. proteins and DNA) and engineered biocompatible nanostructured surfaces, performing AFM for both topographical imaging and combined topographical-mechanical imaging.
Cell adhesion: construct and analyse models, such as cell membranes, for understanding the mechanics and morphology of cell membrane interaction with drugs, liposomes, and (inactive) pathogens and the role of extracellular vesicles in macromolecule transport. It is possible to investigate the interactions between lipid bilayers (as cellular membrane models) and extracellular vesicles (EVs), including fusion processes essential for intracellular cargo release.